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human sclc cell lines nci h146 htb 173  (ATCC)


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    ATCC human sclc cell lines nci h146 htb 173
    TAF1 represses MHC-I expression in SCLC. ( A ) Correlation between TAF1 expression and MHC-I gene expression in the IMpower133 RNA-seq dataset; ( B ) Correlation between TAF1 expression and HLA-C protein levels in the TU-SCLC proteomic dataset; ( C ) Western blot analysis of TAF1 expression in DMS53 cells with or without TAF1 knockdown; β-actin was used as a loading control; ( D ) Flow cytometric analysis of HLA-A/B/C expression in DMS53-sh TAF1 and DMS53-shCtrl cells; ( E ) qPCR analysis of representative HLA expression ( HLA-A , HLA-B , HLA-C ) in DMS53-sh TAF1 versus DMS53-shCtrl cells; ( F ) Western blot analysis of TAF1 expression <t>in</t> <t>NCI-H146</t> cells with or without TAF1 knockdown; β-actin was used as a loading control; ( G ) Flow cytometric analysis of HLA-A/B/C expression in NCI-H146-sh TAF1 and NCI-H146-shCtrl cells; ( H ) Western blot analysis of TAF1 expression in RP cells with or without Taf1 knockdown; β-actin was used as a loading control; ( I ) Flow cytometric analysis of H2Kb/Db expression in RP-sh Taf1 and RP-shCtrl cells; ( J ) Top five downregulated pathways in tumors with high TAF1 expression compared to those with low TAF1 expression in the IMpower133 cohort; ( K ) Top five downregulated pathways enriched in tumor cells with high TAF1 expression compared with low TAF1 expression in Rudin et al. cohort.
    Human Sclc Cell Lines Nci H146 Htb 173, supplied by ATCC, used in various techniques. Bioz Stars score: 95/100, based on 127 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    1) Product Images from "TAF1 Suppresses MHC-I Expression and Correlates with Poor Immunotherapy Response in Small Cell Lung Cancer"

    Article Title: TAF1 Suppresses MHC-I Expression and Correlates with Poor Immunotherapy Response in Small Cell Lung Cancer

    Journal: Biomedicines

    doi: 10.3390/biomedicines14050973

    TAF1 represses MHC-I expression in SCLC. ( A ) Correlation between TAF1 expression and MHC-I gene expression in the IMpower133 RNA-seq dataset; ( B ) Correlation between TAF1 expression and HLA-C protein levels in the TU-SCLC proteomic dataset; ( C ) Western blot analysis of TAF1 expression in DMS53 cells with or without TAF1 knockdown; β-actin was used as a loading control; ( D ) Flow cytometric analysis of HLA-A/B/C expression in DMS53-sh TAF1 and DMS53-shCtrl cells; ( E ) qPCR analysis of representative HLA expression ( HLA-A , HLA-B , HLA-C ) in DMS53-sh TAF1 versus DMS53-shCtrl cells; ( F ) Western blot analysis of TAF1 expression in NCI-H146 cells with or without TAF1 knockdown; β-actin was used as a loading control; ( G ) Flow cytometric analysis of HLA-A/B/C expression in NCI-H146-sh TAF1 and NCI-H146-shCtrl cells; ( H ) Western blot analysis of TAF1 expression in RP cells with or without Taf1 knockdown; β-actin was used as a loading control; ( I ) Flow cytometric analysis of H2Kb/Db expression in RP-sh Taf1 and RP-shCtrl cells; ( J ) Top five downregulated pathways in tumors with high TAF1 expression compared to those with low TAF1 expression in the IMpower133 cohort; ( K ) Top five downregulated pathways enriched in tumor cells with high TAF1 expression compared with low TAF1 expression in Rudin et al. cohort.
    Figure Legend Snippet: TAF1 represses MHC-I expression in SCLC. ( A ) Correlation between TAF1 expression and MHC-I gene expression in the IMpower133 RNA-seq dataset; ( B ) Correlation between TAF1 expression and HLA-C protein levels in the TU-SCLC proteomic dataset; ( C ) Western blot analysis of TAF1 expression in DMS53 cells with or without TAF1 knockdown; β-actin was used as a loading control; ( D ) Flow cytometric analysis of HLA-A/B/C expression in DMS53-sh TAF1 and DMS53-shCtrl cells; ( E ) qPCR analysis of representative HLA expression ( HLA-A , HLA-B , HLA-C ) in DMS53-sh TAF1 versus DMS53-shCtrl cells; ( F ) Western blot analysis of TAF1 expression in NCI-H146 cells with or without TAF1 knockdown; β-actin was used as a loading control; ( G ) Flow cytometric analysis of HLA-A/B/C expression in NCI-H146-sh TAF1 and NCI-H146-shCtrl cells; ( H ) Western blot analysis of TAF1 expression in RP cells with or without Taf1 knockdown; β-actin was used as a loading control; ( I ) Flow cytometric analysis of H2Kb/Db expression in RP-sh Taf1 and RP-shCtrl cells; ( J ) Top five downregulated pathways in tumors with high TAF1 expression compared to those with low TAF1 expression in the IMpower133 cohort; ( K ) Top five downregulated pathways enriched in tumor cells with high TAF1 expression compared with low TAF1 expression in Rudin et al. cohort.

    Techniques Used: Expressing, Gene Expression, RNA Sequencing, Western Blot, Knockdown, Control



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    human sclc cell lines nci h146 htb 173  (ATCC)
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    ATCC human sclc cell lines nci h146 htb 173
    TAF1 represses MHC-I expression in SCLC. ( A ) Correlation between TAF1 expression and MHC-I gene expression in the IMpower133 RNA-seq dataset; ( B ) Correlation between TAF1 expression and HLA-C protein levels in the TU-SCLC proteomic dataset; ( C ) Western blot analysis of TAF1 expression in DMS53 cells with or without TAF1 knockdown; β-actin was used as a loading control; ( D ) Flow cytometric analysis of HLA-A/B/C expression in DMS53-sh TAF1 and DMS53-shCtrl cells; ( E ) qPCR analysis of representative HLA expression ( HLA-A , HLA-B , HLA-C ) in DMS53-sh TAF1 versus DMS53-shCtrl cells; ( F ) Western blot analysis of TAF1 expression <t>in</t> <t>NCI-H146</t> cells with or without TAF1 knockdown; β-actin was used as a loading control; ( G ) Flow cytometric analysis of HLA-A/B/C expression in NCI-H146-sh TAF1 and NCI-H146-shCtrl cells; ( H ) Western blot analysis of TAF1 expression in RP cells with or without Taf1 knockdown; β-actin was used as a loading control; ( I ) Flow cytometric analysis of H2Kb/Db expression in RP-sh Taf1 and RP-shCtrl cells; ( J ) Top five downregulated pathways in tumors with high TAF1 expression compared to those with low TAF1 expression in the IMpower133 cohort; ( K ) Top five downregulated pathways enriched in tumor cells with high TAF1 expression compared with low TAF1 expression in Rudin et al. cohort.
    Human Sclc Cell Lines Nci H146 Htb 173, supplied by ATCC, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    human sclc cell lines h146 htb 173  (ATCC)
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    TAF1 represses MHC-I expression in SCLC. ( A ) Correlation between TAF1 expression and MHC-I gene expression in the IMpower133 RNA-seq dataset; ( B ) Correlation between TAF1 expression and HLA-C protein levels in the TU-SCLC proteomic dataset; ( C ) Western blot analysis of TAF1 expression in DMS53 cells with or without TAF1 knockdown; β-actin was used as a loading control; ( D ) Flow cytometric analysis of HLA-A/B/C expression in DMS53-sh TAF1 and DMS53-shCtrl cells; ( E ) qPCR analysis of representative HLA expression ( HLA-A , HLA-B , HLA-C ) in DMS53-sh TAF1 versus DMS53-shCtrl cells; ( F ) Western blot analysis of TAF1 expression <t>in</t> <t>NCI-H146</t> cells with or without TAF1 knockdown; β-actin was used as a loading control; ( G ) Flow cytometric analysis of HLA-A/B/C expression in NCI-H146-sh TAF1 and NCI-H146-shCtrl cells; ( H ) Western blot analysis of TAF1 expression in RP cells with or without Taf1 knockdown; β-actin was used as a loading control; ( I ) Flow cytometric analysis of H2Kb/Db expression in RP-sh Taf1 and RP-shCtrl cells; ( J ) Top five downregulated pathways in tumors with high TAF1 expression compared to those with low TAF1 expression in the IMpower133 cohort; ( K ) Top five downregulated pathways enriched in tumor cells with high TAF1 expression compared with low TAF1 expression in Rudin et al. cohort.
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    TAF1 represses MHC-I expression in SCLC. ( A ) Correlation between TAF1 expression and MHC-I gene expression in the IMpower133 RNA-seq dataset; ( B ) Correlation between TAF1 expression and HLA-C protein levels in the TU-SCLC proteomic dataset; ( C ) Western blot analysis of TAF1 expression in DMS53 cells with or without TAF1 knockdown; β-actin was used as a loading control; ( D ) Flow cytometric analysis of HLA-A/B/C expression in DMS53-sh TAF1 and DMS53-shCtrl cells; ( E ) qPCR analysis of representative HLA expression ( HLA-A , HLA-B , HLA-C ) in DMS53-sh TAF1 versus DMS53-shCtrl cells; ( F ) Western blot analysis of TAF1 expression <t>in</t> <t>NCI-H146</t> cells with or without TAF1 knockdown; β-actin was used as a loading control; ( G ) Flow cytometric analysis of HLA-A/B/C expression in NCI-H146-sh TAF1 and NCI-H146-shCtrl cells; ( H ) Western blot analysis of TAF1 expression in RP cells with or without Taf1 knockdown; β-actin was used as a loading control; ( I ) Flow cytometric analysis of H2Kb/Db expression in RP-sh Taf1 and RP-shCtrl cells; ( J ) Top five downregulated pathways in tumors with high TAF1 expression compared to those with low TAF1 expression in the IMpower133 cohort; ( K ) Top five downregulated pathways enriched in tumor cells with high TAF1 expression compared with low TAF1 expression in Rudin et al. cohort.
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    TAF1 represses MHC-I expression in SCLC. ( A ) Correlation between TAF1 expression and MHC-I gene expression in the IMpower133 RNA-seq dataset; ( B ) Correlation between TAF1 expression and HLA-C protein levels in the TU-SCLC proteomic dataset; ( C ) Western blot analysis of TAF1 expression in DMS53 cells with or without TAF1 knockdown; β-actin was used as a loading control; ( D ) Flow cytometric analysis of HLA-A/B/C expression in DMS53-sh TAF1 and DMS53-shCtrl cells; ( E ) qPCR analysis of representative HLA expression ( HLA-A , HLA-B , HLA-C ) in DMS53-sh TAF1 versus DMS53-shCtrl cells; ( F ) Western blot analysis of TAF1 expression <t>in</t> <t>NCI-H146</t> cells with or without TAF1 knockdown; β-actin was used as a loading control; ( G ) Flow cytometric analysis of HLA-A/B/C expression in NCI-H146-sh TAF1 and NCI-H146-shCtrl cells; ( H ) Western blot analysis of TAF1 expression in RP cells with or without Taf1 knockdown; β-actin was used as a loading control; ( I ) Flow cytometric analysis of H2Kb/Db expression in RP-sh Taf1 and RP-shCtrl cells; ( J ) Top five downregulated pathways in tumors with high TAF1 expression compared to those with low TAF1 expression in the IMpower133 cohort; ( K ) Top five downregulated pathways enriched in tumor cells with high TAF1 expression compared with low TAF1 expression in Rudin et al. cohort.
    H146, supplied by ATCC, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    TAF1 represses MHC-I expression in SCLC. ( A ) Correlation between TAF1 expression and MHC-I gene expression in the IMpower133 RNA-seq dataset; ( B ) Correlation between TAF1 expression and HLA-C protein levels in the TU-SCLC proteomic dataset; ( C ) Western blot analysis of TAF1 expression in DMS53 cells with or without TAF1 knockdown; β-actin was used as a loading control; ( D ) Flow cytometric analysis of HLA-A/B/C expression in DMS53-sh TAF1 and DMS53-shCtrl cells; ( E ) qPCR analysis of representative HLA expression ( HLA-A , HLA-B , HLA-C ) in DMS53-sh TAF1 versus DMS53-shCtrl cells; ( F ) Western blot analysis of TAF1 expression <t>in</t> <t>NCI-H146</t> cells with or without TAF1 knockdown; β-actin was used as a loading control; ( G ) Flow cytometric analysis of HLA-A/B/C expression in NCI-H146-sh TAF1 and NCI-H146-shCtrl cells; ( H ) Western blot analysis of TAF1 expression in RP cells with or without Taf1 knockdown; β-actin was used as a loading control; ( I ) Flow cytometric analysis of H2Kb/Db expression in RP-sh Taf1 and RP-shCtrl cells; ( J ) Top five downregulated pathways in tumors with high TAF1 expression compared to those with low TAF1 expression in the IMpower133 cohort; ( K ) Top five downregulated pathways enriched in tumor cells with high TAF1 expression compared with low TAF1 expression in Rudin et al. cohort.
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    TAF1 represses MHC-I expression in SCLC. ( A ) Correlation between TAF1 expression and MHC-I gene expression in the IMpower133 RNA-seq dataset; ( B ) Correlation between TAF1 expression and HLA-C protein levels in the TU-SCLC proteomic dataset; ( C ) Western blot analysis of TAF1 expression in DMS53 cells with or without TAF1 knockdown; β-actin was used as a loading control; ( D ) Flow cytometric analysis of HLA-A/B/C expression in DMS53-sh TAF1 and DMS53-shCtrl cells; ( E ) qPCR analysis of representative HLA expression ( HLA-A , HLA-B , HLA-C ) in DMS53-sh TAF1 versus DMS53-shCtrl cells; ( F ) Western blot analysis of TAF1 expression in NCI-H146 cells with or without TAF1 knockdown; β-actin was used as a loading control; ( G ) Flow cytometric analysis of HLA-A/B/C expression in NCI-H146-sh TAF1 and NCI-H146-shCtrl cells; ( H ) Western blot analysis of TAF1 expression in RP cells with or without Taf1 knockdown; β-actin was used as a loading control; ( I ) Flow cytometric analysis of H2Kb/Db expression in RP-sh Taf1 and RP-shCtrl cells; ( J ) Top five downregulated pathways in tumors with high TAF1 expression compared to those with low TAF1 expression in the IMpower133 cohort; ( K ) Top five downregulated pathways enriched in tumor cells with high TAF1 expression compared with low TAF1 expression in Rudin et al. cohort.

    Journal: Biomedicines

    Article Title: TAF1 Suppresses MHC-I Expression and Correlates with Poor Immunotherapy Response in Small Cell Lung Cancer

    doi: 10.3390/biomedicines14050973

    Figure Lengend Snippet: TAF1 represses MHC-I expression in SCLC. ( A ) Correlation between TAF1 expression and MHC-I gene expression in the IMpower133 RNA-seq dataset; ( B ) Correlation between TAF1 expression and HLA-C protein levels in the TU-SCLC proteomic dataset; ( C ) Western blot analysis of TAF1 expression in DMS53 cells with or without TAF1 knockdown; β-actin was used as a loading control; ( D ) Flow cytometric analysis of HLA-A/B/C expression in DMS53-sh TAF1 and DMS53-shCtrl cells; ( E ) qPCR analysis of representative HLA expression ( HLA-A , HLA-B , HLA-C ) in DMS53-sh TAF1 versus DMS53-shCtrl cells; ( F ) Western blot analysis of TAF1 expression in NCI-H146 cells with or without TAF1 knockdown; β-actin was used as a loading control; ( G ) Flow cytometric analysis of HLA-A/B/C expression in NCI-H146-sh TAF1 and NCI-H146-shCtrl cells; ( H ) Western blot analysis of TAF1 expression in RP cells with or without Taf1 knockdown; β-actin was used as a loading control; ( I ) Flow cytometric analysis of H2Kb/Db expression in RP-sh Taf1 and RP-shCtrl cells; ( J ) Top five downregulated pathways in tumors with high TAF1 expression compared to those with low TAF1 expression in the IMpower133 cohort; ( K ) Top five downregulated pathways enriched in tumor cells with high TAF1 expression compared with low TAF1 expression in Rudin et al. cohort.

    Article Snippet: Human SCLC cell lines NCI-H146 (HTB-173) and DMS53 (CRL-2062) were obtained from American Type Culture Collection (ATCC, Manassas, VA, USA).

    Techniques: Expressing, Gene Expression, RNA Sequencing, Western Blot, Knockdown, Control

    KEY RESOURCES TABLE

    Journal: Cell reports

    Article Title: A multiplexed in vivo approach to identify driver genes in small cell lung cancer

    doi: 10.1016/j.celrep.2023.111990

    Figure Lengend Snippet: KEY RESOURCES TABLE

    Article Snippet: Human: NCI-H146 , ATCC , HTB-173; RRID:CVCL_1473.

    Techniques: Plasmid Preparation, Virus, Recombinant, Modification, Labeling, Amplification, Polymer, Staining, Protease Inhibitor, Bicinchoninic Acid Protein Assay, Simple Western, Membrane, DNA Extraction, Purification, Sequencing, Generated, Software

    KEY RESOURCES TABLE

    Journal: Cancer cell

    Article Title: Patterns of transcription factor programs and immune pathway activation define four major subtypes of SCLC with distinct therapeutic vulnerabilities

    doi: 10.1016/j.ccell.2020.12.014

    Figure Lengend Snippet: KEY RESOURCES TABLE

    Article Snippet: Human: H146 cells , ATCC , Cat # HTB-173.

    Techniques: Virus, Recombinant, Methylation, Software